HSP-90 expression as a predictor of response to radiotherapy in head and neck cancer patients.
نویسندگان
چکیده
INTRODUCTION AND OBJECTIVES HSP-90 is an intracellular protein that protects the cell from environmental stress situations. The overexpression of HSP-90 isoforms could serve as a mechanism of resistance to radiotherapy for tumour cells. We studied this effect in a sample of head and neck tumours. METHODS We included 87 patients diagnosed with oral cavity, oropharynx, larynx and hypopharynx tumours. We studied the expression of the HSP-90 isoforms by real-time PCR on pre-treatment biopsy samples. We analysed the relationship between HSP-90 expression levels and local relapse of the tumour with CRT decision trees. RESULTS The expression levels of the inducible citosolic isoform (HSP90AA) allowed the definition of 2 groups of patients with different rates of local relapse. The group with a low expression level showed a 2.9% local relapse rate, while the group with a high expression level showed a 38.2% rate. Survival curves showed differences in time to local relapse for both groups of patients. These differences did not reach statistical significance. CONCLUSIONS Radiotherapy response was related to expression levels of HSP-90 in a sample of head and neck cancer patients. This result could prove useful in the selection of treatments for this group of patients.
منابع مشابه
HSP-90 Expression as a Predictor of Response to Radiotherapy in Head and Neck Cancer Patients
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ورودعنوان ژورنال:
- Acta otorrinolaringologica espanola
دوره 67 3 شماره
صفحات -
تاریخ انتشار 2016